He is desperate to pursue his vocation as an artist.

他不顾地从事艺术的职业。

The racer meant to win the 500-mile race at all hazards.

这位竞赛者决心不顾危险, 赢得这场500英里的车赛。

How often we have been temerarious and rushed unwisely in.

有些可以不顾的为了自己的利益破坏规。

He did it in disregard of any advice.

他不顾劝告做了这件事。

He has the greatest disregard all formality.

他全然不顾节。

She is hellbent on starting it at once.

她不顾地要立刻开始这件事。

The soldiers made a headlong rush for cover.

士兵们不顾冲向掩蔽所。

We clung desperately together.

我们不顾地紧紧抱在起。

The losing gamester,in hopes of retrieving past misfortunes,goes on from bad to worse,till growing desperate,he pushes at everything and loses his all.

他感到绝望，不顾下注，结果血本无归。